Histologic comparison of the uterine pathologic effects of erythropoietin and U-74389G

Abstrak

Background: This manuscript compared the effects of uterine pathology (UP) after processing with either the drug erythropoietin hormone (Epo) or the lazaroid antioxidant agent (L), U-74389G. This comparison was provided by the outcomes of 2 preceding branches.Objective: Both studies estimated the effect after each drug use in a planned uterine ischemia-reperfusion (UIR) mouse experimental setting.Methods: Both principal experiment timepoints, the uterine histology was evaluated, were the minimum 60th after reperfusion (A, C, E groups) and also the minimum 120th after reperfusion (B, D, F groups). Groups A & B were placebo; C & D groups were processed with Epo; and E & F groups were processed after the L process.Results: The one study branch of Epo has shown a barely significant decreasing potency for the total UP within the “lesion-free” grade alteration of -0.0916667 [-0.1907629 - 0.0074296] (p= 0.0583). However, the other study branch of U-74389G showed a non-significant accentuation of the total UP within the “lesion-free” grade alteration of 0.2229748 [-0.1376592 - 0.5836089] (p= 0.4940). Both branch studies were co-evaluated as they belong to a common experiment. Their outcome was that Epo appears to ameliorate UP status, whereas L appears to worsen it; however, the discrepancy was not significant (p= 0.0677).Conclusion: There is a slight non-significant superiority of Epo than L in UIR pathology restoration (p= 0.0677), possibly useful in several clinical situations.