Hydatidiform Mole Complicated by Gestational Hyperthyroidism in a 9- Week Pregnancy (G6P4A1): A Case Report

Abstrak

Gestational trophoblastic disease is an abnormal form of pregnancy characterized by excessive proliferation of trophoblastic tissue, with hydatidiform mole being the most common presentation. Gestational hyperthyroidism is a rare but clinically significant complication resulting from markedly elevated β-human chorionic gonadotropin (β-hCG) levels that stimulate thyroid hormone production. Objective: To report a case of a complete hydatidiform mole complicated by gestational hyperthyroidism and to highlight the importance of early diagnosis. and appropriate management. Methods This study presents a case report of a 40-year-old woman (G6P4A1) at 9 weeks of gestation who presented with vaginal bleeding, hyperemesis, and palpitations. Clinical examination, laboratory investigations, ultrasonography, and histopathological analysis were performed to establish the diagnosis.  Ultrasonography demonstrated a characteristic honeycomb appearance consistent with a complete hydatidiform mole. Laboratory findings revealed suppressed thyroid-stimulating hormone (TSH) levels and elevated thyroxine (T4) levels, indicating gestational hyperthyroidism. The diagnosis was confirmed by histopathological examination following uterine evacuation. The patient was managed with antithyroid medications, beta-blockers, preoperative stabilization, and suction curettage, resulting in a favorable clinical outcome. Conclusion: A complete hydatidiform mole may be associated with gestational hyperthyroidism due to excessive β-hCG production. Early recognition and comprehensive management are essential to prevent maternal complications. Recommendation: Routine assessment of thyroid function should be considered in patients with suspected or confirmed hydatidiform mole to optimize maternal outcomes.