Senggani Leaf Extract-Based Gel Facial Wash: A Herbal Innovation for Anti-Acne Therapy Targeting Cutibacterium acnes

Abstrak

Senggani is a traditional Asian plant commonly used as an alternative medicine, particularly in Indonesia. The leaves of the senggani plant contain secondary metabolites, including tannins, alkaloids, flavonoids, and saponins. Among these, tannins and flavonoids are believed to have antibacterial properties. This study investigates whether a facial wash gel made from the ethanol extract of senggani leaves possesses stable properties and meets established standards. Additionally, the study aims to evaluate its antibacterial activity against Cutibacterium acnes, the bacteria responsible for acne. A maceration method with 70% ethanol was used to prepare the ethanol extract from senggani leaves. This extract was then formulated into a facial wash gel using carbopol polymer at 5%, 7.5%, and 10%, followed by tests to assess its antibacterial activity. The antibacterial activity was determined using the disc diffusion method at the same concentrations. The results indicated that the diameter of the bacterial inhibition zone was 9.93 mm at 5%, 11.66 mm at 7.5%, and 13.93 mm at 10%. The gel preparation of the ethanol extract from senggani leaves demonstrated stable properties, with physical stability evaluations confirming compliance with the quality standards for facial washes set by Indonesian national regulations. Furthermore, the senggani leaf ethanol extract gel effectively inhibited the growth of Cutibacterium acnes, indicating its potential as an effective face wash.