ANTIBREAST CANCER ACTIVITY OF NANOPROPOLIS INDONESIA ON INDUCED MAMMARY GLAND TUMOR BY DMBA IN VIRGIN SPRAGUE–DAWLEY RATS

Abstrak

The objective of this study was to determine the effect of nanopropolis on DMBA-induced mammary tumors in rats. After the first tumor appearance, twenty-eight rats were divided into seven groups. Groups 1, 2, and 3 served as recipients of nanopropolis treatments at dosages of 8, 32, and 56 μg/mL, respectively. Group 4 received propolis at 233 μg/mL, Group 5 served as the treatment control, Group 6 received DMBA only, and Group 7 served as the normal control. The effects of nanopropolis at 32 μg/mL and propolis at 233 μg/mL were similar in reducing tumor size, healing wounds caused by the tumor, and eliminating cancer cells. Furthermore, the study suggested a relationship between particle size of the absorbent material and its effectiveness. Overall, nanopropolis was very effective in treating mammary gland tumors and breast cancer even at small concentrations.